Laboratory for Living Systems Engineering
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Research​

​Mechanobiology of
​Engineered Cardiac Tissue

We use tunable biomaterials, microfabrication techniques, and microscopy to investigate how mechanical cues impact contractility, conduction velocity, and metabolism in engineered cardiac tissues. 
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Engineered MicroMyocardium. Image credit: Nethika Ariyasinghe.
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Engineered cardiac tissue stained for mitochondria. Image credit: Davi Leite.

​​Engineered Microenvironments for Stem Cell Differentiation​

We engineer custom cellular microenvironments to optimize the differentiation of cardiac myocytes from pluripotent stem cells.
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Human induced pluripotent stem cells grown in a pattern. Image credit: Nathan Cho.
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Cardiac myocytes differentiated from human induced pluripotent stem cells. Image credit: Joycelyn Yip.

Microphysi​ological Systems

We microfabricate scalable fluidic devices, known as "Microphysiological Systems" or "Organs on Chips", for culturing human cells in a dynamic environment that mimics native tissue.
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3-D printer printing a fluidic device. Image credit: Andrew Petersen.

​Skeletal Muscle Engineering and
​Disease Modeling​

We engineer robust and functional skeletal muscle tissues with the long-term goal of building models of skeletal myopathies, such as muscular dystrophy.
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Engineered skeletal myotubes. Image credit: Archana Bettadapur, Gio Suh, Holly Huber, Alyssa Viscio, and Evelyn Wang.
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