​Mechanobiology of
​Engineered Cardiac Tissue

We use tunable biomaterials, microfabrication techniques, and microscopy to investigate how mechanical cues impact contractility, conduction velocity, and metabolism in engineered cardiac tissues. 

Engineered MicroMyocardium. Image credit: Nethika Ariyasinghe.

Engineered cardiac tissue stained for mitochondria. Image credit: Davi Leite.

​​Engineered Microenvironments for Stem Cell Differentiation​

We engineer custom cellular microenvironments to optimize the differentiation of cardiac myocytes from pluripotent stem cells.

Human induced pluripotent stem cells grown in a pattern. Image credit: Nathan Cho.

Cardiac myocytes differentiated from human induced pluripotent stem cells. Image credit: Joycelyn Yip.

Microphysi​ological Systems

We microfabricate scalable fluidic devices, known as "Microphysiological Systems" or "Organs on Chips", for culturing human cells in a dynamic environment that mimics native tissue.

3-D printer printing a fluidic device. Image credit: Andrew Petersen.

​Skeletal Muscle Engineering and
​Disease Modeling​

We engineer robust and functional skeletal muscle tissues with the long-term goal of building models of skeletal myopathies, such as muscular dystrophy.

Engineered skeletal myotubes. Image credit: Archana Bettadapur, Gio Suh, Holly Huber, Alyssa Viscio, and Evelyn Wang.