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About Us

The Laboratory for Living Systems Engineering is an interdisciplinary research group within the Department of Biomedical Engineering at the University of Southern California.

Our overarching goal is to engineer micro-scale mimics of human tissues, known as "Organs on Chips", that can be used as platforms for understanding human development and disease and identifying new therapeutic strategies. To achieve this, we use tunable biomaterials and cultured cells (often stem cell derivatives) in combination with a variety of microfabrication techniques to build complex, multi-cellular tissues carefully designed to mimic native tissues. We then quantify the transcriptional, structural, and functional phenotype of our engineered tissues to understand processes of development and/or disease, with a focus on cardiac and skeletal muscle.